Matthew State, MD, PhD
Working Title
Oberndorf Family Distinguished Professor and Chair
Primary Department
Psychiatry and Behavioral Sciences
Preferred Pronouns
he/him/his
Biography
Matthew W. State MD, PhD, is a child psychiatrist and human geneticist studying pediatric neuropsychiatric syndromes.
Matthew W. State MD, PhD, is a child psychiatrist and human geneticist studying pediatric neuropsychiatric syndromes. His lab focuses on gene discovery as a launching point for efforts to illuminate the biology of these conditions and to develop novel and more effective therapies.
Dr. State received his undergraduate and medical degrees at Stanford University, completed his residency in psychiatry and fellowship in child psychiatry at the UCLA Neuropsychiatric Institute, and earned a PhD in genetics from Yale University working in the lab of David C Ward. He was on the faculty at Yale from 2001 to 2013 where he was the Donald J. Cohen Professor of Child Psychiatry, Psychiatry and Genetics and the Co-Founder and Co-Director of the Yale Program on Neurogenetics. He is currently the Oberndorf Family Distinguished Professor and Chair of Psychiatry at UCSF and Director of the Langley Porter Psychiatric Institute and Hospital.
Dr. State's lab has played a leading role in demonstrating the contribution of rare and de novo variation to autism spectrum disorders (ASD), Tourette disorder (TD), and brain malformation syndromes. Recent work has contributed to the identification of dozens of ASD risk genes, the identification of the first high confidence TD genes, and has utilized systems biological approaches to characterize the spatial and temporal convergence of autism genes in developing human brain. Dr. State plays a leadership role in a number of national and international collaborative genomics studies of autism and Tourette disorder, including the Simons Simplex Collection Genomics Consortium, the Autism Sequencing Consortium, and the Tourette International Collaboration (TIC) on Genetics.
Assistant Contact Information: Gigi Lopez, gigi,[email protected], 415-476-7730
Dr. State received his undergraduate and medical degrees at Stanford University, completed his residency in psychiatry and fellowship in child psychiatry at the UCLA Neuropsychiatric Institute, and earned a PhD in genetics from Yale University working in the lab of David C Ward. He was on the faculty at Yale from 2001 to 2013 where he was the Donald J. Cohen Professor of Child Psychiatry, Psychiatry and Genetics and the Co-Founder and Co-Director of the Yale Program on Neurogenetics. He is currently the Oberndorf Family Distinguished Professor and Chair of Psychiatry at UCSF and Director of the Langley Porter Psychiatric Institute and Hospital.
Dr. State's lab has played a leading role in demonstrating the contribution of rare and de novo variation to autism spectrum disorders (ASD), Tourette disorder (TD), and brain malformation syndromes. Recent work has contributed to the identification of dozens of ASD risk genes, the identification of the first high confidence TD genes, and has utilized systems biological approaches to characterize the spatial and temporal convergence of autism genes in developing human brain. Dr. State plays a leadership role in a number of national and international collaborative genomics studies of autism and Tourette disorder, including the Simons Simplex Collection Genomics Consortium, the Autism Sequencing Consortium, and the Tourette International Collaboration (TIC) on Genetics.
Assistant Contact Information: Gigi Lopez, gigi,[email protected], 415-476-7730
- 2021 - Diversity, Equity, and Inclusion Champion Training, University of California
- PhD, 2001 - Department of Genetics, Yale University
- Fellowship, 1997 - Child Psychiatry, UCLA Neuropsychiatric Institute
- Residency, 1995 - Psychiatry, UCLA Neuropsychiatric Institute
- M.D., 1991 - School of Medicine, Stanford University
- BA, 1984 - Political Science, Stanford University
Child Development Disorders, Pervasive
Autistic Disorder
Intellectual Disability
Codon, Nonsense
Mental Disorders
Nerve Tissue Proteins
Neurosciences
Exome
DNA Copy Number Variations
Genomics
Autism Spectrum Disorder
Genetic Association Studies
Tourette Syndrome
Genetic Predisposition To Disease
Gene Expression Regulation, Developmental
- Wilbur Cross Medal, Yale Graduate School Alumni Association, 2020
- Rhoda and Bernard Sarnat International Prize in Mental Health, National Academy of Medicine, 2017
- Tarjan Award, American Academy of Child and Adolescent Psychiatry, 2014
- Elected member, National Academy of Medicine, 2014
- Ruane Prize, Brain and Behavior Research Foundation, 2012
- Annual Top 10 Scientific Breakthroughs, Science Magazine, 2011
- Annual Top 10 Scientific Breakthroughs, Science Magazine, 2005
December 2, 2015 - Illuminating Depression's Circuitry
November 21, 2013 - Web MD on Willsey et al
January 28, 2016 - Autism Speaks names top ten research papers of 2015
October 29, 2014 - Scientists link 60 genes to autism risk
March 20, 2015 - Mathalon and State named to BBRF's list of 2014 major discoveries
September 6, 2013 - The New Science of Mind: Eric Kandel
October 29, 2014 - Dozens of genes associated with autism in new research
September 28, 2015 - New Autism Genes Are Revealed in Largest-Ever Study
October 29, 2014 - Major Autism Studies Identify Dozens of Contributing Genes
October 29, 2014 - San Francisco scientists find autism linked to dozens of genetic mutations
January 28, 2016 - UCSF-led autism genomics study named a Top 10 Research Paper of 2015
March 25, 2013 - May 31, 2028 - Autism Genetics Phase II: Increasing Representation of Human Diversity , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01MH100027
July 27, 2018 - September 30, 2023 - 2/7-Collaborative genomic studies of Tourette Disorder , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01MH115963
August 15, 2018 - May 31, 2023 - 2/2 - Cell Type and Region-Specific Regulatory Networks in Human Brain Development and Disorders , Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01MH116487
April 5, 2017 - January 31, 2022 - 4/4 - The Autism Sequencing Consortium: Autism Gene Discovery in >50,000 Exomes , Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01MH111662
July 21, 2016 - April 30, 2020 - 3/3 Integrative Genomic Analysis of Human Brain Development and Autism , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01MH110928
August 1, 2016 - June 30, 2019 - 1/3 Multidimensional investigation of the etiology of autism spectrum disorder , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01MH109901
September 18, 2014 - May 31, 2019 - 2/3-Identifying regulatory mutations that influence neuropsychiatric disease , Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01MH105575
May 8, 2015 - February 28, 2019 - Integrating the genomics of Autism Spectrum Disorders(ASD) in consanguineous and idiopathic families , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01MH102342
June 15, 2014 - May 31, 2018 - Transcriptional and Epigenetic Signatures of Human Brain Development and Autism , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01MH103339
September 1, 2013 - July 31, 2017 - 4/4 The Autism Sequencing Consortium: Autism gene discovery in >20,000 exomes , Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01MH100239
September 15, 2011 - June 30, 2015 - 2/8-Collaborative genomic studies of Tourette Disorder , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01MH092289
September 30, 2009 - August 31, 2012 - Genomic Profiling and Functional Mutation Analysis in Autism Spectrum Disorders , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: RC2MH089956
September 1, 2006 - November 30, 2011 - The Role of SLITRK1 in Tourette and Related Disorders , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01NS056276
May 1, 2002 - April 30, 2007 - MOLECULAR APPROACHES TO CHILDHOOD PSYCHIATRIC DISORDERS , Principal Investigator . Sponsor: NIH, Sponsor Award ID: K23RR016118
June 1, 2002 - March 31, 2007 - Molecular Cytogenetics and Tourette Disorder , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01NS043520
Contact information
675 18th Street, #5355
San Francisco, CA 94107
United States
Assistant contact information