Andrew Krystal, MD
Working Title
Ray and Dagmar Dolby Distinguished Professor in Psychiatry and Vice Chair for Research
Primary Department
Psychiatry and Behavioral Sciences
Primary Division
Mood, Emotion, and Arousal
Secondary Division
Habit and Reward
Biography
Dr. Krystal is a pioneer in the application of computational modeling to the study of biomarker development using EEG in patients with depression and sleep disorders and application of biomarkers in treatment development clinical trials.
Dr. Krystal is the Ray and Dagmar Dolby Distinguished Professor in the Departments of Psychiatry and Neurology, Vice-Chair for Research in the Department of Psychiatry, Director of the Dolby Family Center for Mood Disorders, Director of the UCSF Interventional Psychiatry Program and Director of the Clinical and Translational Sleep Research Laboratory. His work focuses on the development of biomarkers for mood and sleep disorders and their application in developing novel, personalized treatments for these conditions.
- Fellowship, 1993 - Clinical Research Methodology, Duke University
- Fellowship, 1992 - Sleep Disorders and Clinical Neurophysiology, Duke University/NIMH
- Executive Chief Residency, 1991 - Psychiatry, Duke University
- Residency, 1991 - Psychiatry, Duke University
- M.D., 1987 - Medicine, Duke University
- M.S., 1983 - Biomedical Engineering, M.I.T.
- B.S.E., 1983 - Mechanical Engineering, M.I.T.
Doxepin
Anhedonia
Suicidal Ideation
Electroconvulsive Therapy
Sleep
Electroencephalography
Receptors, Opioid, Kappa
Polysomnography
Hypnotics And Sedatives
Sleep Stages
Narcotic Antagonists
Deep Brain Stimulation
Wakefulness
Sleep Initiation And Maintenance Disorders
Sleep Wake Disorders
Sleep Medicine
Mood And Anxiety Spectrum Disorders
Biomarkers
EEG
Clinical Trials
Brain Stimulation
Pharmacology
September 18, 2018 - Dolby Family Gift Launches New UCSF Center for Mood Disorders
June 15, 2023 - May 31, 2029 - Responsive Neurostimulation for Treatment Resistant Depression , Principal Investigator . Sponsor: NIH, Sponsor Award ID: UH3NS123310
July 1, 2001 - April 30, 2028 - Frontotemporal Dementia: Genes, Images, and Emotions , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01AG019724
April 1, 2025 - March 31, 2028 - Efficacy of kTMP, a novel non-invasive brain stimulation method, for the treatment of anhedonia , UCSF PI . Sponsor: NIH, Sponsor Award ID: P0583216
April 1, 2023 - February 29, 2028 - Determining the circuits and signals of sleep dysfunction in Parkinson's disease through chronic intracranial recordings and closed-loop Deep Brain Stimulation , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01NS131405
March 1, 2023 - February 29, 2028 - A Confirmatory Efficacy Trial of Engaging a Novel Sleep/Circadian Rhythm Target as Treatment for Depression in Adolescents , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01MH129558
July 1, 2022 - April 30, 2027 - Efficacy of digital cognitive behavior therapy for insomnia for the prevention of perinatal depression , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01MH126040
August 1, 2021 - July 31, 2026 - Probing genetics and biology of human sleep homeostasis , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01NS117929
September 10, 2021 - June 30, 2026 - Spatiotemporal dynamics of the human emotion network , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01MH122431
July 1, 2016 - June 30, 2026 - Phase 1 Clinical Trials for Development of Neurotherapeutics , Principal Investigator . Sponsor: NIH, Sponsor Award ID: NINDS-15-01
April 1, 2024 - March 31, 2026 - Remote STATE training for Insomnia in Older Adults. , UCSF PI . Sponsor: NIH, Sponsor Award ID: R44AG076304
April 1, 2023 - March 31, 2026 - Integrating 1H MRS with 2H-Labeled Glucose to Characterize Dynamic Glutamate Metabolism in Major Depressive Disorder. , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R21MH130817
March 1, 2019 - December 31, 2024 - Reward processing in genetic frontotemporal dementia and mood disorders , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01AG059794
July 1, 2021 - June 30, 2024 - Using electrophysiology to index non-invasive brain stimulation effects on reward system neurobiology in depression , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R21MH127432
July 1, 2019 - June 30, 2024 - Comparative effectiveness of zolpidem and cognitive behavioral therapy for insomnia in rural adults COZi-R , UCSF PI . Sponsor: PCORI, Sponsor Award ID: PCORI
September 1, 2018 - June 30, 2024 - Tissue-Specific Insulin Resistance in Obstructive Sleep Apnea: Role of Hypoxia , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01DK117953
July 1, 2018 - June 30, 2024 - Examining the reciprocal effects of racial discrimination and sleep on cardiovascular functioning: An experimental approach , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01HL142051
June 1, 2019 - February 29, 2024 - Clinical Features and Neuropathological Basis of Sleep Wake Behavior in Alzheimer's and PSP , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01AG060477
December 1, 2020 - November 30, 2023 - Deciphering principles of network dynamics underlying depression symptom severity , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R213017912
March 1, 2020 - February 27, 2023 - Trajectories of Insomnia and Impact on Recovery Following Traumatic Brain Injury , UCSF PI . Sponsor: Department of Defense, Sponsor Award ID: P0540824
April 15, 2015 - January 31, 2019 - Transcranial Direct Current Stimulation (tDCS) as a Treatment for Acute Fear , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21MH106772
September 15, 2012 - May 1, 2018 - New Experimental Medicine Studies: Fast-Fail Trials in Mood and Anxiety Spectrum Disorders (FAST-MAS). , Principal Investigator . Sponsor: NIH, Sponsor Award ID: HHS-N271-2012-000006-I
September 22, 2014 - February 28, 2018 - Instrument to Co-register EEG and NIRS for Accurate Sleep Sorting , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21NS085818
November 1, 2011 - October 31, 2017 - Sequenced Therapies for Comorbid and Primary Insomnias , Principal Invetigator . Sponsor: NIH, Sponsor Award ID: R01MH091053
August 3, 2012 - July 31, 2017 - 2/3-Reducing Suicide Ideation Through Insomnia Treatment (REST-IT) , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01MH095780
September 1, 2010 - August 31, 2014 - Nocturnal Deterusor Overactivity In Overactive Bladder Syndrome , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01DK087717
October 1, 2009 - July 31, 2014 - Biomarkers of the Response to CBT for Insomnia in Major Depression , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01HL096492
June 1, 2008 - April 30, 2014 - 3/3-Improving Depression Outcome by Adding CBT for Insomnia to Antidepressants , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01MH079256
July 20, 2007 - May 31, 2009 - Behavioral Insomnia Treatment in Chronic Fatigue Syndrome , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21NR010539
May 1, 1998 - February 28, 2004 - OPTIMIZING ECT STIMULUS DOSING USING THE ICTAL EEG , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R29MH057532
April 1, 1994 - March 31, 1999 - IMPROVING ECT EFFECTIVENESS THROUGH ICTAL EEG ANALYSIS , Principal Investigator . Sponsor: NIH, Sponsor Award ID: K20MH001151